Affymetrix has exclusively licensed HLA*IMP and will be providing tools incorporating this technology for HLA typing from its genotyping array data in the near future. Prior to the introduction of Affymetrix products that will incorporate improved performance versions of HLA*IMP, this web-service HLA typing is being offered for free as a courtesy to non-profit organizations. Commercial entities interested in using HLA*IMP should contact Affymetrix.

  • have SNP genotype data for some individuals?
  • want HLA type information for these individuals?
See the Tutorial for a gentle and the section Documentation for a more thorough introduction.

HLA*IMP will assist you by imputing HLA type information based on SNP genotypes - in an accurate and reliable manner (see Publications for methods and validation results). This service is intended for academic use only - for the legal details, please consult our Terms of Use for details (if you are a non-academic user and want to use our imputation technology, please contact us).

Generally speaking, dense and accurate SNP genotyping data from the xMHC region will enable you to use HLA*IMP on your data. The program works best for samples of European ancestry, but we are working on improving performance for other ethnicities.

Step I: Register or log in

In order to be able to upload your files and get imputations, you need an activated user account. Therefore, please log in now or create a new account.

Existing user

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Create new account

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Step II: Manual and front-end

Download the front-end tool to convert your data to the right formats, and have a look at the Documentation before experimenting with it.


If you use our software in a scientific context, please cite us in your publications. You can find a list of our publications under Publications - in any case, please cite the Dilthey et al. (2010) and Leslie et al. (2008) papers.